Diffusion MRI (dMRI)-based studies in Traumatic Brain Injury have elucidated local and global WM alterations after injury. However, no studies have quantified how repeated concussions affect WM microstucture and coherence. We, therefore, sought to udnerstand how the number of previous concussions impact diffusion metrics. We found that, compared to the control group, there were significant decreases in FA and increases in MD and RD in the corticospinal tract. With respect to the number of concussions, we found that FA actually increased and was related with higher uniformity of the fibers. We believe this is related to aberrant remyelination.
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