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Abstract #1590

White matter alterations in mild traumatic brain injury: A tract-based spatial meta-analysis exploring the effects of trauma type

SuMing Zhang1, Xinyu Hu1, Xuan Bu1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, ChengDu City, China

Many tract-based spatial statistics (TBSS) studies in mild traumatic brain injury (mTBI) have been inconsistent. Meanwhile, there is evidence that trauma type may have an effect on white matter (WM) microstructure in mTBI. We performed a tract-based spatial meta-analysis of mTBI and examined the potential effects of trauma type on regional WM microstructure. Our findings identified the left anterior thalamic radiation and right superior longitudinal fasciculus were the most convergent circuitry affected in mTBI and indicated distinct patterns of anatomical connectivity abnormalities in accident related and sport related mTBI, which highlighted the potential importance of trauma specific alterations in mTBI.

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