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Abstract #1595

3T intracranial vessel wall MRI reveals that arterial wall thickness increases with reducing hematocrit in patients with sickle cell disease

Shuai Yuan1, Larry Davis1, Petrice Cogswell2, Spencer Waddle3, Lori Jordan1, and Manus Donahue4
1Vanderbilt University Medical Center, Nashville, TN, United States, 2Mayo clinic, Rochester, MN, United States, 3Vanderbilt University, Nashville, TN, United States, 4Vanderbilt University Medical Center Department of Radiology, Nashville, TN, United States

Sickle cell disease leads to increased risk of intracranial vasculopathy and stroke. Therefore, sensitive radiological indicators of cerebrovascular disease severity are needed to aid in treatment planning. 3T vessel wall imaging MRI studies demonstrated increased basilar artery wall thickness in sickle cell disease patients and inverse relationship between hematocrit and basilar wall thickness likely due to increased blood flow velocities and wall stress. Evaluation of internal carotid artery is difficult possibly due to variable CSF signal suppression in these regions.

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