Abstract #1595

3T intracranial vessel wall MRI reveals that arterial wall thickness increases with reducing hematocrit in patients with sickle cell disease

Shuai Yuan¹, Larry Davis¹, Petrice Cogswell², Spencer Waddle³, Lori Jordan¹, and Manus Donahue⁴

¹Vanderbilt University Medical Center, Nashville, TN, United States, ²Mayo clinic, Rochester, MN, United States, ³Vanderbilt University, Nashville, TN, United States, ⁴Vanderbilt University Medical Center Department of Radiology, Nashville, TN, United States

Sickle cell disease leads to increased risk of intracranial vasculopathy and stroke. Therefore, sensitive radiological indicators of cerebrovascular disease severity are needed to aid in treatment planning. 3T vessel wall imaging MRI studies demonstrated increased basilar artery wall thickness in sickle cell disease patients and inverse relationship between hematocrit and basilar wall thickness likely due to increased blood flow velocities and wall stress. Evaluation of internal carotid artery is difficult possibly due to variable CSF signal suppression in these regions.

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