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Abstract #1596

 Optimized Intracranial Vessel Wall Imaging Framework – First clinical results

Konstanze Viktoria Anna Valerie Guggenberger1, Patrick Vogel1, Nils Venhoff2, Ute Ludwig3, Marc Schmalzing4, Esther Raithel5, Axel Joachim Krafft3, Thomas Ness6, Jost Hillenkamp7, Horst Urbach8, Stephan Meckel8, and Thorsten Bley1
1Department of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Wuerzburg, Germany, 2Clinic for Rheumatology and Clinical Immunology, University Hospital Freiburg, Freiburg, Germany, 3Department of Radiology, Medical Physics, University Hospital Freiburg, Freiburg, Germany, 4Rheumatology/Clinical Immunology Department, Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany, 5Siemens Healthcare, Erlangen, Germany, 6University Eye Center, University Hospital Freiburg, Freiburg, Germany, 7Department of Ophthalmology, University Hospital Wuerzburg, Wuerzburg, Germany, 8Department of Neuroradiology, University Hospital Freiburg, Freiburg, Germany

The extent of intracranial large artery involvement and its assessment is still part of on-going research. Our study group has developed a whole-brain T1-weighted dark blood CS-SPACE sequence suitable for intracranial vessel wall imaging in large-artery vasculitis combined with a dedicated post-processing tool. 53 patients were analyzed in a prospective blinded two university medical center trial. First clinical results demonstrate the technique`s suitability for clinical application. Mural thickening and contrast-enhancement as well as luminal changes are readily visible. However, certain confounders, especially atherosclerotic vessel wall lesions as well as vasa vasorum still propose major challenges for diagnosing intradural vasculitic affection.

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