Multi-slice single-shot 2D echo-planar imaging (EPI) readout can be used effectively for pseudo-continuous arterial spin labeling (pCASL) perfusion imaging. In this study we tried to utilize the Compressed SENSE reconstruction for pCASL-EPI without further optimization of EPI sampling scheme. pCASL-EPICS clearly reduces noise-like artifacts and significantly improves the robustness of perfusion images in a short scan time less than 3 minutes compared with conventional pCASL SENSE, without any penalty for scan parameters. This technique may be helpful to further assess the many brain diseases.
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