Abstract #1622

Investigating the Optimal Vasoactive Stimulus to Extract Dynamic Cerebrovascular Reactivity Information: Breath holding versus CO2 Challenge

Eva Elisabeth van Grinsven¹, Allen A. Champagne², Marielle Philippens³, and Alex Bhogal⁴

¹Department of Neurology & Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht, Netherlands, ²Center for Neuroscience studies, School of medicine, Queen’s University, Kingston, ON, Canada, ³Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

This study compared multiple BOLD cerebrovascular reactivity (CVR)-metrics during breath holding (BH) versus a targeted CO₂ challenge to determine the degree of similarity in extracting dynamic information about hemodynamic reserves. The preliminary data confirm previous research; CVR-maps were spatially comparable and correlated well between the two stimuli. That said, the data suggests reliable information regarding the flow dynamics is best provided by a controlled CO₂ stimulus. Thus, even though BH may be easier to implement, it may also be limited in its ability to provide additional information regarding cerebrovascular health (beyond CVR), which could be of value when investigating patients.

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