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Abstract #1623

Towards non-invasive estimation of "resting-state" CVR: associations with congenital heart disease, cognition, and nasal nitric oxide

Vincent Jerome Schmithorst1, Cecilia Lo2, Philip Adams2, and Ashok Panigrahy1
1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States, 2University of Pittsburgh, Pittsburgh, PA, United States

Estimation of cerebrovascular reserve/reactivity (CVR) typically necessitates an invasive vasoactive stimulus. We here propose a metric to non-invasively estimate “resting-state” CVR (rCVR), the capacity of the vasculature to respond to resting-state metabolic demand, as the negative ratio of functional connectivity strength (FCS) to regional cerebral blood flow (CBF). Construct validity was demonstrated via prediction of end-tidal CO2 levels (PETCO2). rCVR was lower in older children with congenital heart disease (CHD) in default mode network (DMN), salience network (SN), and central executive network (CEN), and was positively associated with neurocognitive outcome (NIH Toolbox) and nasal nitric oxide (nNO) levels.

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