Recently, flow velocity and pulsatility can be measured in cerebral perforating arteries. However, whether this perforator function is independent of upstream large vessel function is unknown. This study therefore investigates cerebral perforator velocity and pulsatility in the centrum semi-ovale (CSO) and basal ganglia (BG) using 7 Tesla MRI in patients with carotid occlusive disease and controls, and in patients inter-hemispherical. Cerebral perforator function was found to be similar in patients and controls, and also similar between hemispheres of patients with unilateral COD. These results show that cerebral arterial perforator function is independent of upstream large vessel disease.