Abstract #1625

The relationship between cerebral arterial perforator function on 7 Tesla MRI and carotid occlusive disease

Tine Arts¹, Laurien Onkenhout², Doeschka Ferro², Eline Oudeman², Jaap Kappelle², Thijs van Osch³, Jaco Zwanenburg¹, Jeroen Hendrikse¹, and Geert Jan Biessels²

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Neurology, University Medical Center Utrecht, Utrecht, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands

Recently, flow velocity and pulsatility can be measured in cerebral perforating arteries. However, whether this perforator function is independent of upstream large vessel function is unknown. This study therefore investigates cerebral perforator velocity and pulsatility in the centrum semi-ovale (CSO) and basal ganglia (BG) using 7 Tesla MRI in patients with carotid occlusive disease and controls, and in patients inter-hemispherical. Cerebral perforator function was found to be similar in patients and controls, and also similar between hemispheres of patients with unilateral COD. These results show that cerebral arterial perforator function is independent of upstream large vessel disease.

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