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Abstract #1627

Cerebrovascular Atlas: A Novel Framework to Detect Structural Alterations Using MRA

Boyu Zhang1, Bei Wang1, Chengyan Wang2, Ying-Hua Chu3, and He Wang1,2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Human Phenome Institute, Fudan University, Shanghai, China, 3MR Collaboration, Siemens Healthcare Ltd., Shanghai, China

Cerebral vascular alterations are leading risk of several brain diseases. To detect the structural alterations, we proposed the novel framework to automatically generate the cerebrovascular probability atlas and corresponding radius and tortuosity atlas using multistage segmentation and concatenated registration method. 198 hypertension patients and 149 health participants scanned with TOF MRA and T1 sequences were included in our study. The tortuosity in middle cerebral artery and posterior cerebral artery are obviously higher in hypertension group, which may reveal the intrinsic mechanism of cerebrovascular structural changes in hypertension.

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