In this study, we aimed to investigate the feasibility of a hybrid arterial spin labeling (hASL) zero-echo-time (zTE) magnetic resonance angiography (MRA) for intracranial arteries. Comparing with the conventional zTE MRA (continuous ASL, cASL), the hASL-zTE-MRA showed higher signal homogeneity in the proximal intracranial arteries. Additionally, hASL-zTE-MRA provided more robust performance in depicting cerebrovascular diseases, such as stenosis and arteriovenous malformation (AVM). We therefore demonstrated that the utilization of hASL strategy could potentially improve the image quality of zTE-MRA, and further be applied routinely in the clinic for patients with cerebrovascular diseases.
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