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Abstract #1643

Altered Spontaneous Brain Activity in Patients with MELAS at Attack and Remission Stages: Evidence from Resting-state fMRI

Rong Wang1, Yuxin Li1, Jie Lin1, Chong Sun1, Daoying Geng1, and Liqin Yang1
1Huashan Hospital, Shanghai, China

This is the first study that used resting-state fMRI (rs-fMRI) to assess the alterations of spontaneous neuronal activity in patients with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) at attack and remission stages, which may provide a new insight into the mechanisms of cerebral cortex damage in MELAS.

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