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Abstract #1652

One-stop-shop Carotid Pulse Wave Velocity (cPWV) Using a Single-slice 2D Phase-Contrast MRI

Soroush Heidari Pahlavian1,2, Xiaoming Bi3, Samantha Ma1,2, Helena Chui2, Danny J.J. Wang1,2, and Lirong Yan1,2
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, University of Southern California, Los Angeles, CA, United States, 3Siemens Medical Solutions USA Inc., Los Angeles, CA, United States

The association between increased cerebrovascular risk factors induced arterial stiffness, and age-related neurodegenerative disorders has been demonstrated in multiple studies. In this study, we evaluated the utility of single-slice two–dimensional (2D) phase-contrast MRI (PC-MRI) to assess arterial stiffness by calculating the carotid pulse wave velocity (cPWV) along the common carotid artery (CCA) and internal carotid arteries (ICA) within a single two-minute scan. Our results demonstrated the feasibility of cPWV measurement using single-slice 2D PC-MRI and indicated a positive correlation between cPWV and arterial damping factor. 2D PC-MRI-measured cPWV holds potential as biomarker to quantify age-related alterations in arterial stiffness.

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