Abstract #1652

One-stop-shop Carotid Pulse Wave Velocity (cPWV) Using a Single-slice 2D Phase-Contrast MRI

Soroush Heidari Pahlavian^1,2, Xiaoming Bi³, Samantha Ma^1,2, Helena Chui², Danny J.J. Wang^1,2, and Lirong Yan^1,2

¹USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, University of Southern California, Los Angeles, CA, United States, ³Siemens Medical Solutions USA Inc., Los Angeles, CA, United States

The association between increased cerebrovascular risk factors induced arterial stiffness, and age-related neurodegenerative disorders has been demonstrated in multiple studies. In this study, we evaluated the utility of single-slice two–dimensional (2D) phase-contrast MRI (PC-MRI) to assess arterial stiffness by calculating the carotid pulse wave velocity (cPWV) along the common carotid artery (CCA) and internal carotid arteries (ICA) within a single two-minute scan. Our results demonstrated the feasibility of cPWV measurement using single-slice 2D PC-MRI and indicated a positive correlation between cPWV and arterial damping factor. 2D PC-MRI-measured cPWV holds potential as biomarker to quantify age-related alterations in arterial stiffness.

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