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Abstract #1655

Multi-modal assessment of cerebrovascular reactivity by multiband BOLD and multidelay ASL in moyamoya patients using acetazolamide

Pieter T Deckers1, Alex A Bhogal2, Lisa A van der Kleij2, Mathijs BJ Dijsselhof2, Kees PJ Braun3, Jeroen CW Siero2, and Albert Van der Zwan1
1Neurosurgery, UMC Utrecht, Utrecht, Netherlands, 2Radiology, UMC Utrecht, Utrecht, Netherlands, 3Pediatric Neurology, UMC Utrecht, Utrecht, Netherlands

Measuring the cerebral blood flow and cerebrovascular reactivity is vital in the preoperative assessment of moyamoya patients. We propose a combination of continuous multiband BOLD-MRI and multidelay ASL-MRI with acetazolamide as a comprehensive multi-modal alternative for the current commonly used PET-CT method. Eight female patients (age 8-41) were scanned at 3T with a ±30 min scan protocol, which is also suitable for patients scanned under general anesthesia. The obtained reactivity maps of the two sequences showed good agreement for severity and location of hemodynamic impairment. This accessible MRI method is directly suitable for routine clinical evaluation of moyamoya patients.

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