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Abstract #1666

White matter hyperintensity features in Neuropsychiatric Systemic Lupus Erythematosus: a retrospective case-control study.

Francesca Inglese1, Myriam G. Jaarsma-Coes1, Gerda M. Steup-Beekman2, Tom Huizinga2, Mark A. van Buchem1, Itamar Ronen1, and Jeroen de Bresser1
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

Systemic Lupus Erythematosus (SLE) often presents with neuropsychiatric (NP) symptoms. These symptoms can be directly associated with SLE (NP-SLE) or not (non-NP-SLE). We investigated whether white matter hyperintensity (WMH) features (such as type, volume and shape) may contribute to the diagnosis of NP-SLE. Patients with NP-SLE more often had deep WMH (DWMH) compared to patients with non-NP-SLE. There were no significant differences in WMH volume and shape features between NP-SLE patients compared to non-NP-SLE patients. In conclusion, NP-SLE patients more often had DWMH compared to non-NP-SLE patients and this may help in the diagnostic process of NP-SLE.

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