Abstract #1675

Investigation of chemotherapy-induced brain volume and shape change in breast cancer women

Yi-Fang Wu¹, Vincent Chin-Hung Chen^2,3, Yuan-Hsiung Tsai⁴, and Jun-Cheng Weng^1,3,5

¹Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ²School of Medicine, Chang Gung University, Taoyuan, Taiwan, ³Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁴Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Adjuvant chemotherapy has been associated with cognitive impairment among a subgroup of breast cancer patients. A limited number of studies have observed the relationship between adjuvant chemotherapy, post-traumatic stress disorder (PTSD) and structural brain changes. Therefore, we employed voxel-based morphometry (VBM) and vertex-wise shape analyses to find the differences in brain volume and shape among pre- and post-chemotherapy breast cancer patients and healthy subjects. Our results showed gray and white matter volume alterations in frontal and temporal brain regions among each group. We also observed the change of shape in the limbic system.

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