Abstract #1676

Relationship between GluCEST concentration and Perivascular Spaces (glia-lymphatic waste clearance pathways) at 7T in Acute Ischemic Stroke

Benjamin Sinclair^1,2, John-Paul Nicolo^1,2,3,4, David Wright¹, Bradford Moffat⁵, Andrew Neale^1,2,3,4, Nian Yu^6,7, Elaine Lui^8,9, Patricia Desmond^8,9, Rebecca Glarin^8,9, Kathryn Davis¹⁰, Ravi Prakash Nanga¹¹, Ravinder Reddy¹¹, Farshid Sepehrband¹², Bernard Yan^3,4, Scott Kolbe¹, Patrick Kwan^1,2,3,4, Terence J O'Brien^1,2,3,4, and Meng Law^1,6

¹Department of Neuroscience, Monash University, Melbourne, Australia, ²Department of Neurology, Alfred Hospital, Melbourne, Australia, ³Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia, ⁴Department of Medicine, University of Melbourne, Melbourne, Australia, ⁵Melbourne Node of the National Imaging Facility, Department of Radiology, University of Melbourne, Melbourne, Australia, ⁶Department of Radiology, Alfred Hospital, Melbourne, Australia, ⁷Department of Radiology, The Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China, ⁸Department of Radiology, Royal Melbourne Hospital, Melbourne, Australia, ⁹Department of Radiology and Medicine, University of Melbourne, Melbourne, Australia, ¹⁰Penn Epilepsy Center, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States, ¹¹Center for Magnetic Resonance & Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ¹²USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

In this pilot study we test the hypothesis that glutamate levels post-stroke are influenced by glia-lymphatic clearance pathways in the brain. Excess glutamate can be neurotoxic, and stroke is associated with focally elevated gluatamate concentrations. Perivascular spaces have recently been found to play a role in waste clearance in the brain, and often become enlarged when compromised. We used Chemical Exchange Saturation Transfer (CEST) imaging at 7T to characterise glutamate concentrations, and found that they were moderately positively correlated with scores of enlarged pervivascular spaces.

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