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Abstract #1677

Choroid plexus and gray matter perfusion dissimilarity in patients with cerebrovascular disease: implications for CSF dynamics and glymphatics

Skylar E Johnson1, Colin McKnight1, Spencer Waddle1, Maria Garza1, Lori C Jordan1,2,3, Daniel O Claassen3, and Manus J Donahue1,3,4
1Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States, 2Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, United States, 3Neurology, Vanderbilt University School of Medicine, Nashville, TN, United States, 4Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, United States

The goal of this study is to investigate whether choroid plexus (CP) activity, quantified as perfusion measured from arterial spin labeling, is altered in patients with cerebrovascular disease. Cohorts comprised arterial intracranial stenosis (n=56), sickle cell disease (n=41), and healthy controls (n=31). In controls and stenosis patients, CP and gray matter perfusion were similar; in patients with sickle cell disease, CP-to-gray matter perfusion was reduced (p<0.001) relative to other cohorts. This finding is discussed in the context of how efficient CSF perivascular flow surrounding dilated arterial spaces may require reduced CSF production activity to subserve waste clearance.

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