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Abstract #1690

Dilated PVS affects surrounding white matter non-parenchymal water fraction differently in healthy young and elderly CSVD individuals

Yeerfan Jiaerken1,2 and Zhang Minming1
1Second Affiliated Hospital of Zhejiang University, School Of Medicine, hangzhou, China, 2UNC Chapel Hill, chapel hill, NC, United States

We investigated how dilated perivascular space (dPVS) affects water drainage in surrounding tissue and whether there is any distance-related pattern of water distribution around dPVS. We found that The isotropic diffusing water content was higher within dPVS, compared to contralateral normal white matter, and the CSVD subjects had higher within-dPVS water content than healthy subjects, and dPVS showed different distance-related pattern in healthy subjects and subjects with severe CSVD, suggesting dPVS played different roles in healthy subjects and CSVD.

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