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Abstract #1691

An anatomic atlas of brain metastases: probability maps based on 13 primary cancer subtypes from post-contrast T1-weighted MRI of 955 patients

Jeremiah W Sanders1, Jason M Johnson2, Henry Szu-Meng Chen1, Melissa Chen2, Maria Gule-Monroe2, Zijian Zhou1, Tina M Briere3, Jing Li4, Jingfei Ma1, and Ho-Ling Liu1
1Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Neuroradiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 3Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, United States

Metastasis is regarded as a highly inefficient process in that less than 0.01% of circulating tumor cells eventually succeeds in forming secondary tumor growths. The seed and soil theory suggests that certain tumor cells have a specific affinity for the milieu of certain organs. Numerous studies have attempted to better understand the biology behind the distribution of brain metastasis and theories include both variables involving the metastasis and the target brain parenchyma. This work establishes probabilistic maps of locations where 13 primary cancer subtypes metastasize to the brain from T1-weighted MRIs of 955 patients undergoing stereotactic radiosurgery.

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