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Abstract #1698

Effects of Chemo-Radiation on Normal Appearing White Matter in GBM patients

Hatef Mehrabian1, Mark Ruschin2, Sten Myrehaug3,4, Hany Soliman1,3,4, Arjun Sahgal1,3,4, and Greg J Stanisz1,5
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Physics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Radiation Oncology, University of Toronto, Toronto, ON, Canada, 5Medical Biophysics, University of Toronto, Toronto, ON, Canada

Chemo-radiation treatment for GBM damages normal brain tissues and leads to significant deterioration in patients’ quality of life months or years after treatment. Magnetization transfer (MT) is sensitive to white matter damage and may detect it early. We observed significant reduction in MT exchange rate (RM0B) that quantifies white matters integrity as early as one month after 6-week chemo-radiation. The treatment impact on normal brain tissue was observed even in regions that received low radiation dose. More importantly, not all patients experienced MT reduction showing the heterogeneity of response to treatment and the potential of MT in identifying vulnerable patients.

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