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Abstract #1697

Characterization of Brain Tumors using Amide Proton and Nuclear Overhauser Effect at 3 Tesla MR Scanner.

Yuki Kanazawa1, Masafumi Harada1, Mitsuharu Miyoshi2, Takashi Abe1, Yuki Matsumoto1, and Yasushi Takagi3
1Tokushima University, Tokushima, Japan, 2Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, 3Department of Neurosurgery, Tokushima University, Tokushima, Japan

To achieve detailed characterization of brain tumors, we demonstrated CEST imaging with multi-pool model [bulk water, magnetization transfer (MT), amide proton transfer (APT), and nuclear Overhauser effect (NOE)] derive from the Bloch equation. This study was performed using five patients with brain tumors. As a result, there was high linearity between MTRasym and T2/T1 in each tumor (R2 = 0.91, P<0.05). Moreover, there were significantly different NOE signals for tumors and normal white matter (P<0.05). Detection using APT and NOE make it possible to provide more detailed information of brain tumors than MTRasym analysis.

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