Abstract #1705

Response prediction of the vestibular schwannoma after gamma-knife radiosurgery using DCE-MRI: preliminary results after 1-year follow-up.

Inpyeong Hwang¹, Seung Hong Choi¹, Jin Wook Kim², Roh-Eul Yoo¹, Koung Mi Kang¹, Tae Jin Yun¹, Ji-hoon Kim¹, and Chul-ho Sohn¹

¹Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea, Republic of

There are few known predictive factors for response to gamma-knife radiosurgery (GKRS) in vestibular schwannoma (VS). This study investigated the relationship between DCE-MR derived pharmacokinetic parameters and tumor volume change at one year after GKRS follow-up in VS. This prospective study performed a volumetric measurement of DCE-MR pharmacokinetic parameters before GKRS. The patients underwent followed-up MR at post one year, tumor volume was measured, and pharmacokinetic parameters were compared between tumor growth group and stable group. Only the K^trans value showed statistical differences. Our results suggest that K^trans value has the potential to predict tumor response in VS after GKRS.

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