There are few known predictive factors for response to gamma-knife radiosurgery (GKRS) in vestibular schwannoma (VS). This study investigated the relationship between DCE-MR derived pharmacokinetic parameters and tumor volume change at one year after GKRS follow-up in VS. This prospective study performed a volumetric measurement of DCE-MR pharmacokinetic parameters before GKRS. The patients underwent followed-up MR at post one year, tumor volume was measured, and pharmacokinetic parameters were compared between tumor growth group and stable group. Only the Ktrans value showed statistical differences. Our results suggest that Ktrans value has the potential to predict tumor response in VS after GKRS.