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Abstract #1705

Response prediction of the vestibular schwannoma after gamma-knife radiosurgery using DCE-MRI: preliminary results after 1-year follow-up.

Inpyeong Hwang1, Seung Hong Choi1, Jin Wook Kim2, Roh-Eul Yoo1, Koung Mi Kang1, Tae Jin Yun1, Ji-hoon Kim1, and Chul-ho Sohn1
1Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, 2Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea, Republic of

There are few known predictive factors for response to gamma-knife radiosurgery (GKRS) in vestibular schwannoma (VS). This study investigated the relationship between DCE-MR derived pharmacokinetic parameters and tumor volume change at one year after GKRS follow-up in VS. This prospective study performed a volumetric measurement of DCE-MR pharmacokinetic parameters before GKRS. The patients underwent followed-up MR at post one year, tumor volume was measured, and pharmacokinetic parameters were compared between tumor growth group and stable group. Only the Ktrans value showed statistical differences. Our results suggest that Ktrans value has the potential to predict tumor response in VS after GKRS.

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