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Abstract #1706

Pixel-wise and regional comparison of a low flip angle, single-dose versus moderate flip angle, double-dose DSC-MRI protocol

Laura C. Bell1, Leland S. Hu2, Yuxiang Zhou2, Kathleen M. Schmainda3, Jerrold L. Boxerman4, and C. Chad Quarles1
1Barrow Neurological Institute, Phoenix, AZ, United States, 2Mayo Clinic, Scottsdale, AZ, United States, 3Medical College of Wisconsin53226, Milwaukee, WI, United States, 4Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States

Current recommendations for brain tumor dynamic susceptibility contrast MRI include the use of a moderate flip angle (MFA) and a full standard preload dose.1 Recently, simulations2 identified an equally accurate protocol that requires no preload and uses a low flip angle (LFA) and optimized echo time. This was validated in vivo3 by comparing LFA- and MFA-based mean tumor cerebral blood volume. Here we aim to systematically characterize agreement by evaluating the pixel-wise agreement in enhancing tumor, edema, white matter, and gray matter regions. We found high agreement in all regions further strengthening the clinical utility of the LFA protocol.

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