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Abstract #1707

Analysis of Accuracy and Precision of Recommended Protocols for Dynamic Susceptibility Contrast MRI for Brain Metastases

Natenael B Semmineh1, Usha Bhalla2, Laura C Bell1, Ashley M Stokes1, Matthew D Lee3, Leland Hu4, Jerrold L Boxerman3,5, and C Chad Quarles1
1Division of Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Brown University, Providence, RI, United States, 3Alpert Medical School - Brown University, Providence, RI, United States, 4Department of Radiology, Mayo Clinic Arizona, phoenix, AZ, United States, 5Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, United States

Numerous methods have been proposed to overcome the confounding influence of contrast agent leakage on DSC-MRI derived CBV maps in brain tumors. Recently, we leveraged a digital reference object to identify the optimal acquisition and analysis methods for GBM patients, a protocol that is now being recommended as the standardized approach for all clinical scans. It is unknown if the biological differences between GBM and metastases would confound the use of this protocol in patients with brain metastases. In this study we characterize the influence of this GBM-centric protocol resulted in lower metastases CBV accuracy and precision.

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