Abstract #1712

Increased cerebral blood volume in cortical and subcortical brain regions in Glioblastoma patients after EPI distortion correction

Ivar Thokle Hovden¹, Oliver M. Geier¹, Ingrid Digernes¹, Elies Fuster-Garcia¹, Grethe Løvland², Einar Vik-Mo³, Torstein R. Meling^3,4, and Kyrre E. Emblem¹

¹Department of Diagnostic Physics, Oslo University Hospital, Oslo, Norway, ²The Intervention Centre, Oslo University Hospital, Oslo, Norway, ³Department of Neurosurgery, Oslo University Hospital, Oslo, Norway, ⁴Department of Neurosurgery, Geneva University Hospitals, Geneva, Switzerland

We studied the changes in rCBV introduced by echo-planar imaging (EPI) distortion correction methods when applied to EPI dynamic susceptibility contrast (DSC)-MRI. The results obtained using FSL TOPUP and EPIC distortion correction methods indicate that both subcortical and cortical regions are affected and returning an overall increase in rCBV. In the context of longitudinal EPI-based analysis in glioblastoma patients, EPI distortions and subsequent corrections are important determiners for assessing robust responses of rCBV change.

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