Meeting Banner
Abstract #1752

Comparison of advanced quantitative diffusion MRI parameter in a multi-site MR study using the traveling volunteer approach

Daniel Güllmar1, Renat Sibgatulin1, Stefan Ropele2, and Jürgen R Reichenbach1,3
1Medical Physics Group / IDIR, Jena University Hospital, Jena, Germany, 2Department of Neurology, Medical University of Graz, Graz, Austria, 3Michael-Stifel-Center for Data driven sciences, Friedrich-Schiller-University Jena, Jena, Germany

If quantitative diffusion measures are acquired at different sites but identical hardware and protocol settings, it remains unclear if a site bias would require a data homogenization in order to pool the data for analysis. A traveling volunteer (including four subjects) approach was applied and different complex diffusion measure as well as diffusion tensor metrics were computed based on the measurements at two different sites. Our results suggest that the inter-site differences are much smaller than the inter-subject differences in the ROI based analysis. The voxel-wise analysis was found to be more susceptible to incomplete artifact compensation and registration errors.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here