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Abstract #1753

Assessing and comparing the suitability of 3D Gradient Echo and VIBE for quantifying subtle blood-brain barrier leakage

Nicholas G Dowell1, Nourah Alruwais2, Paul S Tofts1, and Jennifer Rusted2
1CISC, Brighton and Sussex Medical School, Brighton, United Kingdom, 2School of Psychology, University of Sussex, Brighton, United Kingdom

There is increasing interest in measuring leakage across the blood-brain barrier (BBB) to assess its response to pathology, inflammation or ageing. Quantifying permeability of the BBB is typically performed using dynamic contrast enhanced (DCE) MRI which involves repeated T1-weighted imaging following administration of a Gd contrast agent. In this work, we assess the suitability of two popular DCE acquisition approaches to BBB permeability: (1) a slow gradient echo approach and (2) fast T1-weighted imaging using the VIBE technique . We discuss the advantages and disadvantages of both techniques and recommend the optimum technique for quantification of subtle BBB permeability.

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