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Abstract #1758

Try this at home: Ex vivo Human Brain at 200 Micron Resolution with a Simple Set Up.

Sanghoon Kim1, Ken Sakaie1, Mark J Lowe1, and Stephen E Jones1
1Cleveland Clinic Imaging Institute, CLEVELAND, OH, United States

Postmortem, whole-brain MRI provides an opportunity to investigate anatomy at spatial resolution approaching that of histology without the distortions and limited coverage inherent to histology. Previous work with ex vivo imaging has been done using a sophisticated process with additional steps, such as a custom-built vibration apparatus to remove air bubbles, proton-free oil to eliminate background signal and modifications to the image reconstruction hardware to deal with the large quantity of imaging data as well as a custom RF coil. The results shown here suggest that similar data can be readily acquired without taking extraordinary or costly measures.

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