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Abstract #1760

Quantifying Cerebral Microbleeds using MPRAGE-based Quantitative Susceptibility Mapping

Nashwan Naji1, Myrlene Gee1, Glen C. Jickling2, Richard Camicioli2, and Alan H. Wilman1
1Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Division of Neurology, University of Alberta, Edmonton, AB, Canada

The MPRAGE sequence is commonly included in brain studies for structural imaging using magnitude images; however, its phase images can provide an opportunity to assess microbleed burden using Quantitative Susceptibility Mapping (QSM). In this study, the mean susceptibility and the cross-sectional area of cerebral microbleeds were assessed using a susceptibility map derived from the phase of the MPRAGE sequence, with comparison to QSM measurements based on standard multi-echo gradient-echo. Microbleeds were well visualized on MPRAGE-QSM with susceptibility generally higher on MPRAGE-QSM, mostly due to mismatch in spatial resolution and SNR.

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