The MPRAGE sequence is commonly included in brain studies for structural imaging using magnitude images; however, its phase images can provide an opportunity to assess microbleed burden using Quantitative Susceptibility Mapping (QSM). In this study, the mean susceptibility and the cross-sectional area of cerebral microbleeds were assessed using a susceptibility map derived from the phase of the MPRAGE sequence, with comparison to QSM measurements based on standard multi-echo gradient-echo. Microbleeds were well visualized on MPRAGE-QSM with susceptibility generally higher on MPRAGE-QSM, mostly due to mismatch in spatial resolution and SNR.
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