The asymmetric spin echo technique (ASE) can be used to collect maps of R2’ and calculate cerebral oxygen extraction fraction (OEF). However, these models require extravascular signal only, which is often not fully achieved in standard ASE approaches. Here, a vascular-space-occupancy (VASO) prepulse is used to null intravascular signal in a novel VASO-ASE method, and repeatability measurements of parenchymal versus extravascular R2’ are presented. VASO-ASE was found to provide physiological OEF (34.1±5.3%) and higher reproducibility in controls compared to standard ASE.
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