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Abstract #1763

Isotropic High-Resolution Brain T1rho Mapping with 3D FLAIR MAPSS at 3T

Qi Peng1, Can Wu2, Xiaojuan Li3, Michael L Lipton1, and Craig Branch1
1Gruss Magnetic Resonance Research Center, Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States, 2Philips Healthcare, Andover, MA, United States, 3Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States

Quantitative T1rho (T1ρ) mapping MRI has recently gained wider clinical/research application in human brain imaging. However, high resolution 3D brain T1rho mapping on clinical scanners is still time consuming with compromised quantitative accuracy due to image blurring or artifacts. We propose a 3D FLAIR MAPSS T1rho imaging scheme, which combines CSF-suppression with 3D MAPSS sequence for improved quantitative accuracy in T1rho mapping. Phantom, volunteer, and patient studies validated its sensitivity and reliability for isotropic high resolution of voxel size (1.3mm)3 quantitative mapping using continuous-wave or adiabatic RF pulse T1rho preparation, acquired within clinically acceptable scan duration at 3T.

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