Quantitative susceptibility mapping (QSM) is an important technique for quantifying iron content in the brain. The conventional time of high spatial QSM data is too long. Compressed sensing acceleration (CS) technique can primarily reduce the acquisition time. We sought to evaluate the accuracy and stability of whole brain QSM on both the voxel-wise level and regional level by using several CS accelerations. We found significant differences in the magnetic susceptibility values on voxel-based QSM, but no statistically different in regions of interest. CS acceleration is feasible for QSM acquisition without influence the magnetic susceptibility values obviously.