Sequences that allow volumetric parametric maps are being developed but when these techniques will be available clinically is uncertain. MDME sequence is a robust method, allowing rapid acquisition of T1, T2 relaxation times, PD from which one can generate synthetic multi-contrast images. However, acquisition at thin slices is challenging. With a deep learned reconstruction method, we demonstrate that interleaved thin slice acquisition of MDME, can produce quasi-volumetric synthetic MRI at an isotropic resolution. Limitations include motion misregistrations between acquisitions, parallel imaging/partial volume/pulsation related artifacts, which we believe can be overcome with technical development.
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