Abstract #1785

Metabolite activity in the anterior cingulate cortex during a painful stimulus using functional MRS

Jessica Archibald^1,2, Erin L MacMillan^3,4,5, Carina Graf^2,6, Piotr Kozlowski^2,7,8, Cornelia Laule^2,9,10, and John LK Kramer^1,2,11

¹Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Image Tech Lab, Simon Fraser University, Vancouver, BC, Canada, ⁵Philips Healthcare Canada, Vancouver, BC, Canada, ⁶Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁷Radiology, University of British Columbia, vancouver, BC, Canada, ⁸UBC MRI Research Centre, Vancouver, BC, Canada, ⁹Physics and Astronomy, University of British Columbia, vancouver, BC, Canada, ¹⁰Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ¹¹School of Kinesiology, University of British Columbia, Vancouver, BC, Canada

Current treatment evaluation procedures of pain conditions are dependent on self-reported measures. The objective of this study was to determine changes in excitatory neurotransmitters (i.e., glutamate and glutamate+glutamine) in the anterior cingulate cortex as an objective measure of pain during a painful stimulus using single voxel functional magnetic resonance spectroscopy (fMRS). Glutamate concentration changes during the painful stimulus suggest a role for glutamate in detecting pain which was not related to self-reported pain ratings. An exploratory analysis on sex revealed an 8.63% (p=0.08) increase in glutamate at pain onset in female participants compared with a 7.45% (p=0.31) increase in males.

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