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Abstract #1795

Patterns of grey matter atrophy in patients with MS: a multivariate analysis using source-based morphometry

Paola Valsasina1, Maria A. Rocca1,2, Alessandro Meani1, Claudio Gobbi3, Chiara Zecca3, Alex Rovira4, Xavier Montalban5, Hugh Kearney6, Olga Ciccarelli6, Lucy Matthews7, Jacqueline Palace7, Antonio Gallo8, Alvino Bisecco8, Carsten Lukas9, Barbara Bellenberg9, Frederik Barkhof10,11, Hugo Vrenken10, Paolo Preziosa1,2, and Massimo Filippi1,2,12
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Department of Neurology, Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland, 4Section of Neuroradiology and MRI Unit, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 5Department of Neurology/Neuroimmunology, Multiple Sclerosis Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 6NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, 7Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 8Department of Advanced Medical and Surgical Sciences, and 3T MRI Center, University of Campania “Luigi Vanvitelli”, Naples, Italy, 9Department of Radiology and Nuclear Medicine, and Institute of Neuroradiology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany, 10Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, Netherlands, 11Institutes of Neurology and Healthcare Engineering, University College London, London, United Kingdom, 12Vita-Salute San Raffaele University, Milan, Italy

In this study, we used source-based morphometry to identify patterns of grey matter tissue loss in a large, multicenter cohort of patients with multiple sclerosis (MS) acquired at 8 European sites. We detected a differential involvement of grey matter networks across the different stages of the disease. Cortical and subcortical grey matter atrophy progressed significantly in MS patients over 1-year of follow-up. Grey matter atrophy, especially in the sensorimotor network, was able to explain patients’ clinical disability, while cerebellar atrophy was able to predict clinical disability worsening over 1-year follow-up.

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