Abstract #1795

Patterns of grey matter atrophy in patients with MS: a multivariate analysis using source-based morphometry

Paola Valsasina¹, Maria A. Rocca^1,2, Alessandro Meani¹, Claudio Gobbi³, Chiara Zecca³, Alex Rovira⁴, Xavier Montalban⁵, Hugh Kearney⁶, Olga Ciccarelli⁶, Lucy Matthews⁷, Jacqueline Palace⁷, Antonio Gallo⁸, Alvino Bisecco⁸, Carsten Lukas⁹, Barbara Bellenberg⁹, Frederik Barkhof^10,11, Hugo Vrenken¹⁰, Paolo Preziosa^1,2, and Massimo Filippi^1,2,12

¹Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, ²Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, ³Department of Neurology, Neurocenter of Southern Switzerland, Civic Hospital, Lugano, Switzerland, ⁴Section of Neuroradiology and MRI Unit, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ⁵Department of Neurology/Neuroimmunology, Multiple Sclerosis Centre of Catalonia, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ⁶NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, ⁷Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ⁸Department of Advanced Medical and Surgical Sciences, and 3T MRI Center, University of Campania “Luigi Vanvitelli”, Naples, Italy, ⁹Department of Radiology and Nuclear Medicine, and Institute of Neuroradiology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany, ¹⁰Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, Amsterdam, Netherlands, ¹¹Institutes of Neurology and Healthcare Engineering, University College London, London, United Kingdom, ¹²Vita-Salute San Raffaele University, Milan, Italy

In this study, we used source-based morphometry to identify patterns of grey matter tissue loss in a large, multicenter cohort of patients with multiple sclerosis (MS) acquired at 8 European sites. We detected a differential involvement of grey matter networks across the different stages of the disease. Cortical and subcortical grey matter atrophy progressed significantly in MS patients over 1-year of follow-up. Grey matter atrophy, especially in the sensorimotor network, was able to explain patients’ clinical disability, while cerebellar atrophy was able to predict clinical disability worsening over 1-year follow-up.

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