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Abstract #1796

Higher b-value diffusion improves correlation with cortical myelin content

Sandy Mournet1,2, Gosuke Okubo1,2,3, Ismail Koubiyr1,2, Valentin H Prevost4, Clémence Bal2, Bei Zhang5, Hiroshi Kusahara 4, Nobuyasu Ichinose4, Bruno Triaire4, Bassem Hiba6, Vincent Dousset1,2,7, and Thomas Tourdias1,2,7
1Neurocentre Magendie, INSERM U1215, Bordeaux, France, 2Université de Bordeaux, Bordeaux, France, 3Department of Radiology, Tenri Hospital, Nara, Japan, 4Canon Medical Systems Corporation, Otawara, Japan, 5Canon Medical systems Europe, Paris, France, 6Centre de neuroscience cognitive, CNRS UMR 5229, Université Claude Bernard Lyon, Lyon, France, 7Neuroimagerie diagnostique et thérapeutique, CHU de Bordeaux, Bordeaux, France

In diffusion MRI, the use of very high b-value remains very challenging. In this study, we scanned 9 volunteers with a protocol of dMRI sequences using b values from 1000 to 5000 s/mm². We compared cortical surface map of myelin (T1wi/T2wi) to maps of mean diffusivity (MD) computed from each b value. As opposed to b1000 s/mm², MD maps from b3000 and b5000 inversely mirrored the myelin maps. With increasing b-values, multiple regression models confirmed an increasing negative association between myelin and MD. The MD obtained with high b-value is sensitive to subtle cellular variations such as the cortical myeloarchitecture.

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