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Abstract #1801

Glial changes induced by lipopolysaccharide inflammatory challenge in humans detected with diffusion-weighted MRS

Itamar Ronen1, Francesca Branzoli2, Alessandro Colasanti3, Iris Asllani3, Riccardo De Marco3, Neil Harrison4, and Mara Cercignani3
1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Centre for NeuroImaging Research - CENIR, Brain and Spine Institute - ICM, Paris, France, 3Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom, 4Cardiff University Brain Research Imaging Centre (CUBRIC), School of Medicine, Cardiff University, Cardiff, United Kingdom

Neuroinflammation is a pathomechanism implicated in several neruological, neurodegenerative and psychiatric disorders and is expressed in activation of microglia, the resident brain macrophages. Currently the only neuroimaging method for detecting microglial activation is PET with translocator protein (TSPO) ligands. A well-known model of experimentally inducing systemic inflammation is the administration of lipopolysaccharides (LPS). Here we report a significant increase in the apparent diffusion coefficient of the glial metabolite choline (tCho) in the human thalamus, following injection of LPS. This finding suggests that the ADC(tCho) is a putative marker for glial activation and may be useful in measuring neuroinflammation in disease.

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