Amide proton transfer (APT) imaging is a novel and promising MRI contrast method, but it can be time-consuming. Common parallel imaging methods, like SENSE, can lead to reduced quality of APT. Here, compressed sensing technique is evaluated for the acceleration of APT in brain. The purpose of the present study is to explore feasibility of different acceleration factors in brain APT. The results show that it is feasible to apply accelerator factor 5 to APT display of brain tissue and brain tumor, which could reduce the scan time with in 1 min.