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Abstract #1807

Optimization of k-space Filtering for Compensating T2 Blurring in 3D ASL-MRI: Application to GBM

Yiming Wang1, Limin Zhou1, Joshua S. Greer1,2, Edward Pan3,4,5, Marco C. Pinho1,6, Joseph A. Maldjian1,6, and Ananth J. Madhuranthakam1,6
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States, 3Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, United States, 4Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, United States, 5Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX, United States, 6Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

3D arterial spin labeled (ASL) MRI using turbo spin echo (TSE) acquisition suffers from image blurring, due to T2 decay along the echo train. In this study, a k-space filtering method proposed earlier was optimized to compensate T2 blurring, incorporating ASL T2 measurements in healthy volunteers for T2 decay estimation. This method was then applied to 3D ASL images acquired in healthy volunteers and patients with glioblastoma (GBM) from an ongoing clinical trial. Results showed reduced image blurring in both volunteers and patients.

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