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Abstract #1809

Multiparametric brain MR Imaging for the assessment of Multiple Sclerosis disease progression over 6 months

Xiaomeng Zhang1, Xiaoqing Yang2, Karthikeyan Subramanian3, Bradley A Hooker1, Mark Haacke3, Ivonne Suridjan1, Qi Guo1, Robert Comley1, Adam Ziemann4, and Yanping Luo1
1Translational imaging, iSAT, Abbvie Inc., North Chicago, IL, United States, 2Data & Statistical Sciences, Abbvie Inc., North Chicago, IL, United States, 3Wayne state university, Detroit, MI, United States, 4Neuroscience Development, Abbvie Inc., North Chicago, IL, United States

Quantitative brain MRI was used to evaluate 18 RRMS patients and 10 age matched controls at baseline and 6 months. The study aimed to assess test-retest reproducibility in healthy controls, disease variability in the RRMS population, and sensitivity to disease progression of each MRI-derived parameter. The results will inform the selection of MRI measures to be used as biomarkers in future clinical trials. In addition, longitudinal multiparametric assessment of MS lesions may improve our understanding of different pathological components of such lesions (e.g. inflammation, demyelination, and iron accumulation) during disease progression.

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