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Abstract #1813

Evaluation of Ultrafast Wave-CAIPI 3D FLAIR Versus Standard 3D FLAIR for Quantitative Analysis of White Matter Lesions

Chanon Ngamsombat1,2, Maria Gabriela Figueiro Longo1,3, Augusto Lio M. Gonçalves Filho1,3, Stephen F. Cauley1,4, Kawin Setsompop1,4,5, Qiyuan Tian1, Qiuyun Fan1, Daniel Polak6,7, Wei Liu8, Wei-Ching Lo7, Ramon Gilberto González3,4, Pamela W. Schaefer3,4, John E. Kirsch1,3, Otto Rapalino3,4, John Conklin1,3, and Susie Y. Huang1,3,5
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Faculty of Medicine, Siriraj Hospital Mahidol Univerity, Bangkok, Thailand, 3Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, Boston, MA, United States, 4Harvard Medical School, Boston, MA, United States, 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 6Department of Physics and Astronomy, Heidelberg University, Heidelberg, Heidelberg, Germany, 7Siemens Healthineers AG, Erlangen, Erlangen, Germany, 8Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, Shenzhen, China

Quantification of cerebral white matter lesion volume has become increasingly feasible for routine clinical evaluation and research due to the availability of automated segmentation tools and 3D FLAIR sequences. However, these sequences suffer from long acquisition times, limiting their widespread use. We demonstrate that quantitative white matter lesion volumes estimated using ultrafast Wave-CAIPI SPACE-FLAIR obtained in <3 minutes show excellent agreement with standard SPACE-FLAIR requiring >7 minutes of scanning in patients undergoing clinical evaluation for suspected MS and epilepsy. Wave-CAIPI SPACE-FLAIR may facilitate the adoption of 3D FLAIR sequences for lesion evaluation in patients with MS and other white matter diseases.

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