Abstract #1818

Diffusion Imaging Correlates of Neurocognition in Healthy Adults: The Potentials of Sequences with Multiple Diffusion Encoding Schemes

Khin Khin Tha^1,2, Daisuke Sawamura³, Xinnan Li³, Yuta Urushibata⁴, Keita Ogawa⁵, Kohsuke Kudo^1,2, and Hiroki Shirato²

¹Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ²Global Station for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan, ³Department of Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, ⁴Siemens Healthcare, Tokyo, Japan, ⁵Department of Rehabilitation, Hokkaido University Hospital, Sapporo, Japan

This prospective study was aimed to identify the diffusion imaging correlates of neurocognition. Newly developed diffusion-imaging sequences, i.e., oscillating gradient spin-echo (OGSE), pulsed gradient spin-echo (PGSE), and double diffusion encoding (DDE) sequences, were acquired in 30 healthy adults. The diffusion imaging indices were tested for correlation with the neuropsychological test scores. The microscopic fractional anisotropy (υFA) and fractional anisotropy (FA) of the right caudate nucleus, the υFA of the right temporal lobe, and the OGSE sequence-derived apparent diffusion coefficient (ADC) of the right sublobar white matter showed significant correlations with forward digit span test or trail-making test part-B.

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