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Abstract #1818

Diffusion Imaging Correlates of Neurocognition in Healthy Adults: The Potentials of Sequences with Multiple Diffusion Encoding Schemes

Khin Khin Tha1,2, Daisuke Sawamura3, Xinnan Li3, Yuta Urushibata4, Keita Ogawa5, Kohsuke Kudo1,2, and Hiroki Shirato2
1Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 2Global Station for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan, 3Department of Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, 4Siemens Healthcare, Tokyo, Japan, 5Department of Rehabilitation, Hokkaido University Hospital, Sapporo, Japan

This prospective study was aimed to identify the diffusion imaging correlates of neurocognition. Newly developed diffusion-imaging sequences, i.e., oscillating gradient spin-echo (OGSE), pulsed gradient spin-echo (PGSE), and double diffusion encoding (DDE) sequences, were acquired in 30 healthy adults. The diffusion imaging indices were tested for correlation with the neuropsychological test scores. The microscopic fractional anisotropy (υFA) and fractional anisotropy (FA) of the right caudate nucleus, the υFA of the right temporal lobe, and the OGSE sequence-derived apparent diffusion coefficient (ADC) of the right sublobar white matter showed significant correlations with forward digit span test or trail-making test part-B.

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