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Abstract #1819

Microscopic fractional anisotropy measurements from double diffusion encoding for human brain tumor diagnosis

Masaaki Hori1,2, Masanori Ozaki3, Hiroshi Kusahara4, Masahiro Abe4, Shuji Sato5, Seiko Shimizu6, Kouhei Kamiya1,7, Toshiaki Akashi2, Koji Kamagata2, and Shigeki Aoki2
1Toho University Omori Medical Center, Tokyo, Japan, 2Radiology, Juntendo University School of Medicine, Tokyo, Japan, 3Research and Development Center, Canon Medical Systems Corporation, Kanagawa, Japan, 4Advanced MRI development PJ Team, Canon Medical Systems Corporation, Kanagawa, Japan, 5Juntendo University Hospital, Tokyo, Japan, 6Canon Medical Systems Corporation, Tokyo, Japan, 7Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan

We investigated the values and image contrast of μFA using double diffusion encoding in patients with brain tumors in vivo, as a preliminary study. In general, μFA showed higher values than FA did in the brain tumors. There is no correlation among μFA and FA and ADC, in the meningiomas and solid part of glioblastoma and malignant lymphoma. However, more investigation will be needed to establish the usefulness of μFA in clinical use.

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