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Abstract #1820

Quantitative Measurement of Cerebral Oxygen Extraction in Patients with Sickle Cell Disease after Diamox Infusion Using Asymmetric Spin Echo

Jian Shen1, Chau Vu1, Soyoung Choi2, Aart Nederveen3, and John Wood1,4
1Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 2Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, 3Academic Medical Center, Amsterdam, Netherlands, 4Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States

This study demonstrated tissue oxygen extraction change in patients with sickle cell disease after Acetazolamide injection using Asymmetric Spin Echo technique, and compared with global oxygen extraction change revealed by TRUST. The results suggested that global oxygen extraction decreased as blood flow increased, while tissue oxygen extraction remained stable. And this mismatch might be a proof to the existence of "physiological shunting".

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