Abstract #1820

Quantitative Measurement of Cerebral Oxygen Extraction in Patients with Sickle Cell Disease after Diamox Infusion Using Asymmetric Spin Echo

Jian Shen¹, Chau Vu¹, Soyoung Choi², Aart Nederveen³, and John Wood^1,4

¹Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, ³Academic Medical Center, Amsterdam, Netherlands, ⁴Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States

This study demonstrated tissue oxygen extraction change in patients with sickle cell disease after Acetazolamide injection using Asymmetric Spin Echo technique, and compared with global oxygen extraction change revealed by TRUST. The results suggested that global oxygen extraction decreased as blood flow increased, while tissue oxygen extraction remained stable. And this mismatch might be a proof to the existence of "physiological shunting".

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