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Abstract #1837

Quantitative mapping of brain tissue oxygenation around neural interfaces

Babak Moghadas1, Arati Sridharan1, Livia De Mesquita1, Yuka Sugamura1, Jitendran Muthuswamy1, and Vikram D Kodibagkar1
1Biomedical engineering, Arizona State University, Tempe, AZ, United States

There is a significant need to spatially map the pO2 levels around chronically implanted neural devices to assess the impact on surrounding tissue. Here we apply a quantitative MRI based oximetry approach to map pO2 around neural interfaces. Electrodes were coated with polydimethylsiloxane matrix and soaked in tetradecamethylhexasiloxane, which was characterized and used as a 1H MR pO2 reporter along with the previously developed PISTOL technique. Tissue pO2 in response to air and oxygen breathing was successfully measured from around implanted electrodes. Future studies will combine single-unit electrophysiology with quantitative, high resolution spatial maps of pO2 levels in vivo.

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