There is a significant need to spatially map the pO2 levels around chronically implanted neural devices to assess the impact on surrounding tissue. Here we apply a quantitative MRI based oximetry approach to map pO2 around neural interfaces. Electrodes were coated with polydimethylsiloxane matrix and soaked in tetradecamethylhexasiloxane, which was characterized and used as a 1H MR pO2 reporter along with the previously developed PISTOL technique. Tissue pO2 in response to air and oxygen breathing was successfully measured from around implanted electrodes. Future studies will combine single-unit electrophysiology with quantitative, high resolution spatial maps of pO2 levels in vivo.
This abstract and the presentation materials are available to members only; a login is required.