Abstract #1838

CMRO2 and slow-wave activity are inversely related during sleep: findings from concurrent EEG and OxFlow MRI.

Alessandra Caporale¹, Hyunyeol Lee¹, Hui Lei², Hengyi Rao³, Michael C Langham¹, Alessandra A Caporale², and Felix W Wehrli¹

¹Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, ²Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, ³Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

Radial OxFlow, a technique able of measuring cerebral metabolic rate of oxygen (CMRO₂) dynamically, has been combined with simultaneous electroencephalography (EEG) recording, during the natural onset of sleep and maintenance during a 50-min period of scanning. During sleep, CMRO₂ (measured continuously with an effective temporal resolution of 3.4 seconds) decreased up to 24% with respect to pre-sleep wakefulness. CMRO₂ changes were positively correlated with heart rate (r²=0.25-0.48, P<0.0005), and negatively with changes in EEG slow-wave activity (r²=0.41-0.67, P<0.005), when sleep onset and maintenance occurred.

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