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Abstract #1838

CMRO2 and slow-wave activity are inversely related during sleep: findings from concurrent EEG and OxFlow MRI.

Alessandra Caporale1, Hyunyeol Lee1, Hui Lei2, Hengyi Rao3, Michael C Langham1, Alessandra A Caporale2, and Felix W Wehrli1
1Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 2Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States, 3Psychiatry, Division of Sleep and Chronobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States

Radial OxFlow, a technique able of measuring cerebral metabolic rate of oxygen (CMRO2) dynamically, has been combined with simultaneous electroencephalography (EEG) recording, during the natural onset of sleep and maintenance during a 50-min period of scanning. During sleep, CMRO2 (measured continuously with an effective temporal resolution of 3.4 seconds) decreased up to 24% with respect to pre-sleep wakefulness. CMRO2 changes were positively correlated with heart rate (r2=0.25-0.48, P<0.0005), and negatively with changes in EEG slow-wave activity (r2=0.41-0.67, P<0.005), when sleep onset and maintenance occurred.

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