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Abstract #1840

Multimodal Quantitative Magnetic Resonance Imaging in Adolescent Idiopathic Scoliosis

Bertwin Zhicheng Chen1, Reuben Chee Cheong Soh1,2, Septian Hartono2,3, Chu Ning Ann3, Ming-Ching Wen3, Weiling Lee1, Soo Lee Lim4, Julian Gan5, Yew Long Lo2,3, and Ling Ling Chan1,2
1Singapore General Hospital, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3National Neuroscience Institute, Singapore, Singapore, 4National Heart Centre Singapore, Singapore, Singapore, 5Siemens Healthineers, Singapore, Singapore

The aetiopathogenesis of adolescent idiopathic scoliosis (AIS) remains elusive, with studies suggesting a neurological basis. Using a case control, multimodal approach incorporating volumetry and diffusion tensor imaging, we characterised brain MRI changes in AIS. The pontine volume was significantly larger while left insula was smaller in patients than controls. Whole brain Tract-Based Spatial Statistics (TBSS) showed no difference between subject cohorts. Tractography of the corticoreticular pathway (CRP), which innervates the axial muscles, showed significant differences in mean and axial diffusivity between the left and right CRP only in the patient cohort, but no such asymmetry in the control cohort.

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