Alzheimer’s Disease (AD) has been categorized into familial (~5%) and sporadic AD (~95%). Familial cases are genetic whereas sporadic AD (sAD) is acquired during individual’s lifespan. Intracerebroventricular(icv) streptozotocin(stz) administered animals has been shown to resemble AD phenotype through many molecular studies. In this study we have investigated the impact of icv-stz treatment on memory and neurometabolic activity by infusion of [1,6-13C2]Glucose and [2-13C]Acetate in conjunction with NMR spectroscopy. Our findings have shown the compromised memory, perturbed neurometabolic homeostasis along with decreased synaptic neurotransmission across glutamatergic and GABAergic synapse in cortical and hippocampal brain regions of icv-stz treated mouse.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords