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Abstract #1856

Neuronal and Astroglial Metabolism in icv-STZ Mouse Model of Alzheimer’s Disease: A 1H-[13C]-NMR Study

Narayan Datt Soni1, Dipak Roy2, Akila Ramesh2, and Anant Bahadur Patel2
1NMR spectroscopy and Microimaging, CSIR-CCMB, Hyderabad, India, 2NMR Spectroscopy and Microimaging, CSIR-CCMB, Hyderabad, India

Alzheimer’s Disease (AD) has been categorized into familial (~5%) and sporadic AD (~95%). Familial cases are genetic whereas sporadic AD (sAD) is acquired during individual’s lifespan. Intracerebroventricular(icv) streptozotocin(stz) administered animals has been shown to resemble AD phenotype through many molecular studies. In this study we have investigated the impact of icv-stz treatment on memory and neurometabolic activity by infusion of [1,6-13C2]Glucose and [2-13C]Acetate in conjunction with NMR spectroscopy. Our findings have shown the compromised memory, perturbed neurometabolic homeostasis along with decreased synaptic neurotransmission across glutamatergic and GABAergic synapse in cortical and hippocampal brain regions of icv-stz treated mouse.

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