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Abstract #1855

Diffusion of NAA as a marker for tau pathology in Alzheimer's disease - a combined diffusion weighted MRS and positron emission tomography study.

Nicola Spotorno1, Markus Nilsson2, Boel Hansson2, Felix Andersson3, Antonie Leuzy3, Danielle van Westen2, Oskar Hansson3, and Itamar Ronen4
1Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Diagnostic Radiology, Lund University, Lund, Sweden, 3Department of clinical sciences Malmö, Lund University, Lund, Sweden, 4Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Intraneuronal tau accumulation is a hallmark of Alzheimer's disease. Currently, positron emission tomography with tau specific ligands (Tau-PET) is the only neuroimaging method for measuring tau in AD. In this study that combines Tau-PET with diffusion weighted MRS we show that the apparent diffusion coefficient of NAA, a neuronal metabolite, is significantly lower in AD patients compared to healthy controls in a brain region that shows elevated levels of uptake of the tau-PET ligand. Standard MRS data shows elevated level of glial metabolites, suggesting concomitant gliosis of neuroinflamation. We propose ADC(tNAA) as a putative marker for tau aggregation in AD.

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