Abstract #1854

Neurochemistry and cognition across age: Examining the link between working memory and neuronal and glial markers measured with 1H-MRS at 7T

Anouk Marsman¹, Anna Lind¹, Esben Thade Petersen^1,2, Hartwig Roman Siebner^1,3,4, and Carl-Johan Boraxbekk^1,5,6

¹Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ²Center for Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark, Lyngby, Denmark, ³Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, ⁵Department of Radiation Sciences, Umeå University, Umeå, Sweden, ⁶Institute of Sports Medicine Copenhagen, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

Ageing has been associated with widespread neurochemical changes and cognitive decline. The increased sensitivity and resolution of 1H-MRS at 7T could shed new light on the potential relationship between neurochemistry and cognition during ageing. Our data show that primarily levels of glial metabolic markers, and not neuronal markers, differed between younger, middle-aged and older normal individuals and were correlated with visuo-spatial working memory performance across these age groups. This suggests that glial markers may be more affected by ageing than neuronal markers and that there is a potential association between glial markers and visuo-spatial working memory performance during ageing.

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